Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test.
نویسندگان
چکیده
PURPOSE To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
منابع مشابه
Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test.
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ورودعنوان ژورنال:
- Acta cirurgica brasileira
دوره 23 5 شماره
صفحات -
تاریخ انتشار 2008